Fugu: A Compact Reference Vertebrate Genome
The fugu (Fugu rubripes) genome project was initiated in 1989 by Sydney Brenner and his colleagues Greg Elgar, Sam Aparicio and Byrappa Venkatesh. In 1993, this team showed that the fugu genome is only 390 Mb, about one-eighth the size of the human genome, yet it contains a similar repertoire of genes to humans (Brenner et al., Nature 366:265-268, 1993). Therefore, fugu was proposed as a useful model for annotating the human genome. This, in fact, ushered in the era of comparative genomics. Fugu genome is among the smallest vertebrate genomes and has proved to be a useful ‘reference’ genome for identifying genes and other functional elements such as regulatory elements in human and other vertebrate genomes, and for understanding the structure and evolution of vertebrate genomes. A ‘draft’ sequence of the fugu genome was determined by the International Fugu Genome Consortium in 2002 using the 'whole-genome shotgun' sequencing strategy. The results of the assembly (v2) are reported in Science 297:1301-1310 (2002). Fugu is the second vertebrate genome to be sequenced, the first being the human genome. This webpage presents the annotation made on the fifth assembly (v5) by the IMCB team using the Ensembl annotation pipeline.